LoboVault Home
 

Paralimbic structural abnormalities in psychopathy : a voxel-based morphometry study

LoboVault

Please use this identifier to cite or link to this item: http://hdl.handle.net/1928/9796

Paralimbic structural abnormalities in psychopathy : a voxel-based morphometry study

Show full item record

Title: Paralimbic structural abnormalities in psychopathy : a voxel-based morphometry study
Author: Cope, Lora
Advisor(s): Kiehl, Kent
Committee Member(s): Hutchison, Kent
Clark, Vince
Department: University of New Mexico. Dept. of Psychology
Subject(s): psychopathy
VBM
imaging
MRI
LC Subject(s): Brain--Psychophysiology
Antisocial personality disorders--Etiology.
Antisocial personality disorders--Physiological aspects.
Psychopaths--Physiology.
Affective neuroscience.
Neuropsychology.
Brain--Magnetic resonance imaging.
Degree Level: Masters
Abstract: Previous functional neuroimaging studies of psychopathy have demonstrated abnormal functioning in several brain regions associated with emotion and decision-making, including amygdala, orbital frontal cortex, insula, cingulate, anterior superior temporal gyrus, and parahippocampal gyrus. However, investigations of structural differences in these regions are sparse. The relation between structural abnormalities and psychopathy was investigated using Voxel-Based Morphometry (VBM) and the Psychopathy Checklist-Revised (PCL-R). Factor analysis of the PCL-R has revealed a two factor model that was utilized here. Seventy-seven participants from a community sample of substance users were scanned using high-resolution structural magnetic resonance imaging and assessed for psychopathy using the PCL-R. VBM was used to investigate morphometric differences correlated with PCL-R total score, factor one (interpersonal/affective), and factor two (behavioral/antisocial). Results showed a negative correlation between gray matter concentration and total PCL-R score in middle and superior temporal areas, inferior parietal cortex, middle occipital gyrus, caudate, and posterior cingulate. A similar result was found for factor two. There was a negative correlation between gray matter concentration and factor one score in several regions, including bilateral insula, bilateral middle temporal gyri, bilateral superior temporal gyri, right temporal pole, bilateral amygdala/parahippocampal gyri, right orbital frontal cortex, bilateral anterior and posterior cingulate, and thalamus. These results are consistent with functional studies showing abnormal functioning in paralimbic regions.
Graduation Date: July 2009
URI: http://hdl.handle.net/1928/9796

Files in this item

Files Size Format View
Cope Thesis Manuscript.pdf 1.137Mb PDF View/Open

This item appears in the following Collection(s)

Show full item record

UNM Libraries

Search LoboVault


Advanced Search

Browse

My Account