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Identification of the wings apart transcriptional unit in Drosophila melanogaster


Please use this identifier to cite or link to this item: http://hdl.handle.net/1928/21061

Identification of the wings apart transcriptional unit in Drosophila melanogaster

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dc.contributor.author Morriss, Ginny
dc.date.accessioned 2012-08-28T16:49:02Z
dc.date.available 2012-08-28T16:49:02Z
dc.date.issued 2012-08-28
dc.date.submitted July 2012
dc.identifier.uri http://hdl.handle.net/1928/21061
dc.description.abstract Muscle development is an evolutionarily conserved process. Mechanisms that govern the development of specific muscles in invertebrates can inform our understanding of how vertebrate muscles form. Understanding these processes allows us to translate developmental mechanisms to disease pathogenesis, as similar genes and developmental processes are affected by these diseases. In this dissertation, CG14614 is identified as the gene responsible for the wings apart phenotype in Drosophila melanogaster. This mutation leads to a loss of the adult jump muscle (TDT) in most cases and a greater than 60% reduction in muscle fibers in its least severe form. wap mutants fail to properly form neuromuscular junctions to the TDT, resulting in degeneration of the muscle. Regulation of Myocyte enhancer factor 2 (Mef2) expression in the developing mesoderm, which gives rise to somatic, visceral, and cardiac muscle, by the transcription factors Twist and Mad was also investigated. Our results indicate these are both involved in regulation of the Mef2 enhancer but additional complexity exists in its regulation that remains to be fully elucidated. en_US
dc.language.iso en_US en_US
dc.subject myogenesis en_US
dc.subject development en_US
dc.subject gene regulation en_US
dc.subject Drosophila en_US
dc.subject.lcsh Myogenesis.
dc.subject.lcsh Genetic regulation.
dc.subject.lcsh Muscles--Genetic aspects.
dc.subject.lcsh Drosophila melanogaster.
dc.title Identification of the wings apart transcriptional unit in Drosophila melanogaster en_US
dc.type Dissertation en_US
dc.description.degree Biology en_US
dc.description.level Doctoral en_US
dc.description.department University of New Mexico. Biology Dept. en_US
dc.description.advisor Cripps, Richard
dc.description.committee-member Stricker, Stephen
dc.description.committee-member Takacs-Vesbach, Cristina
dc.description.committee-member Gelbart, William

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