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A fMRI study of auditory orienting and inhibition of return in pediatric mild traumatic brain injury


Please use this identifier to cite or link to this item: http://hdl.handle.net/1928/20893

A fMRI study of auditory orienting and inhibition of return in pediatric mild traumatic brain injury

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dc.contributor.author Yang, Zhen
dc.date.accessioned 2012-07-06T16:55:51Z
dc.date.available 2012-07-06T16:55:51Z
dc.date.issued 2012-07-06
dc.date.submitted May 2012
dc.identifier.uri http://hdl.handle.net/1928/20893
dc.description.abstract Studies in adult mild traumatic brain injury (mTBI) have shown that two key measures of attention, spatial reorienting and inhibition of return (IOR), are impaired during the first few weeks of injury. However, it is currently unknown whether similar deficits exist following pediatric mTBI. The current study used fMRI to investigate the effects of semi-acute mTBI (< 3 weeks post-injury) on auditory orienting in 14 pediatric mTBI patients (age 13.50 ± 1.83; education: 6.86 ± 1.88) and 14 healthy controls (age 13.29 ± 2.09; education: 7.21 ± 2.08) matched for age and years of education. Results indicated that patients with mTBI showed subtle (i.e., moderate effect sizes) but non-significant deficits on formal neuropsychological testing and during inhibition of return. In contrast, functional imaging results indicated that patients with mTBI demonstrated significantly decreased activation within the bilateral posterior cingulate gyrus, thalamus, basal ganglia, midbrain nuclei, and cerebellum. The spatial topography of hypoactivation was very similar to our previous study in adults, suggesting that subcortical structures may be particularly affected by the initial biomechanical forces in mTBI. Current results also suggest that fMRI may be a more sensitive tool for identifying semi-acute effects of mTBI than the procedures currently used in clinical practice such as neuropsychological testing and structural scans. fMRI findings could potentially serve as a biomarker for measuring the subtle injury caused by mTBI and documenting the course of recovery. en_US
dc.description.sponsorship This dissertation was supported by the Graduate Dean's Dissertation Fellowship sponsored by the Office of Graduate Studies and The Benjamin Franklin Haught Scholarship sponsored by the Department of Psychology, University of New Mexico. This research was also supported by grants from The Mind Research Network [DOE Grant No. DE-FG02-99ER62764] through Dr. Andrew Mayer. en_US
dc.language.iso en_US en_US
dc.subject fMRI en_US
dc.subject traumatic brain injury en_US
dc.subject pediatric en_US
dc.subject auditory orienting en_US
dc.subject bottom-up en_US
dc.subject.lcsh Brain injuries--Magnetic resonance imaging.
dc.subject.lcsh Brain-damaged children.
dc.subject.lcsh Auditory perception in children--Physiological aspects.
dc.title A fMRI study of auditory orienting and inhibition of return in pediatric mild traumatic brain injury en_US
dc.type Dissertation en_US
dc.description.degree Psychology en_US
dc.description.level Doctoral en_US
dc.description.department University of New Mexico. Dept. of Psychology en_US
dc.description.advisor Yeo, Ronald
dc.description.committee-member Mayer, Andrew
dc.description.committee-member Clark, Vince
dc.description.committee-member Phillips, John

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