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dc.contributor.authorYang, Zhen
dc.date.accessioned2012-07-06T16:55:51Z
dc.date.available2012-07-06T16:55:51Z
dc.date.issued2012-07-06
dc.date.submittedMay 2012
dc.identifier.urihttp://hdl.handle.net/1928/20893
dc.description.abstractStudies in adult mild traumatic brain injury (mTBI) have shown that two key measures of attention, spatial reorienting and inhibition of return (IOR), are impaired during the first few weeks of injury. However, it is currently unknown whether similar deficits exist following pediatric mTBI. The current study used fMRI to investigate the effects of semi-acute mTBI (< 3 weeks post-injury) on auditory orienting in 14 pediatric mTBI patients (age 13.50 ± 1.83; education: 6.86 ± 1.88) and 14 healthy controls (age 13.29 ± 2.09; education: 7.21 ± 2.08) matched for age and years of education. Results indicated that patients with mTBI showed subtle (i.e., moderate effect sizes) but non-significant deficits on formal neuropsychological testing and during inhibition of return. In contrast, functional imaging results indicated that patients with mTBI demonstrated significantly decreased activation within the bilateral posterior cingulate gyrus, thalamus, basal ganglia, midbrain nuclei, and cerebellum. The spatial topography of hypoactivation was very similar to our previous study in adults, suggesting that subcortical structures may be particularly affected by the initial biomechanical forces in mTBI. Current results also suggest that fMRI may be a more sensitive tool for identifying semi-acute effects of mTBI than the procedures currently used in clinical practice such as neuropsychological testing and structural scans. fMRI findings could potentially serve as a biomarker for measuring the subtle injury caused by mTBI and documenting the course of recovery.en_US
dc.description.sponsorshipThis dissertation was supported by the Graduate Dean's Dissertation Fellowship sponsored by the Office of Graduate Studies and The Benjamin Franklin Haught Scholarship sponsored by the Department of Psychology, University of New Mexico. This research was also supported by grants from The Mind Research Network [DOE Grant No. DE-FG02-99ER62764] through Dr. Andrew Mayer.en_US
dc.language.isoen_USen_US
dc.subjectfMRIen_US
dc.subjecttraumatic brain injuryen_US
dc.subjectpediatricen_US
dc.subjectauditory orientingen_US
dc.subjectbottom-upen_US
dc.subject.lcshBrain injuries--Magnetic resonance imaging.
dc.subject.lcshBrain-damaged children.
dc.subject.lcshAuditory perception in children--Physiological aspects.
dc.titleA fMRI study of auditory orienting and inhibition of return in pediatric mild traumatic brain injuryen_US
dc.typeDissertationen_US
dc.description.degreePsychologyen_US
dc.description.levelDoctoralen_US
dc.description.departmentUniversity of New Mexico. Dept. of Psychologyen_US
dc.description.advisorYeo, Ronald
dc.description.committee-memberMayer, Andrew
dc.description.committee-memberClark, Vince
dc.description.committee-memberPhillips, John


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