LoboVault Home
 

A fMRI study of auditory orienting and inhibition of return in pediatric mild traumatic brain injury

LoboVault

Please use this identifier to cite or link to this item: http://hdl.handle.net/1928/20893

A fMRI study of auditory orienting and inhibition of return in pediatric mild traumatic brain injury

Show full item record

Title: A fMRI study of auditory orienting and inhibition of return in pediatric mild traumatic brain injury
Author: Yang, Zhen
Advisor(s): Yeo, Ronald
Committee Member(s): Mayer, Andrew
Clark, Vince
Phillips, John
Department: University of New Mexico. Dept. of Psychology
Subject(s): fMRI
traumatic brain injury
pediatric
auditory orienting
bottom-up
LC Subject(s): Brain injuries--Magnetic resonance imaging.
Brain-damaged children.
Auditory perception in children--Physiological aspects.
Degree Level: Doctoral
Abstract: Studies in adult mild traumatic brain injury (mTBI) have shown that two key measures of attention, spatial reorienting and inhibition of return (IOR), are impaired during the first few weeks of injury. However, it is currently unknown whether similar deficits exist following pediatric mTBI. The current study used fMRI to investigate the effects of semi-acute mTBI (< 3 weeks post-injury) on auditory orienting in 14 pediatric mTBI patients (age 13.50 ± 1.83; education: 6.86 ± 1.88) and 14 healthy controls (age 13.29 ± 2.09; education: 7.21 ± 2.08) matched for age and years of education. Results indicated that patients with mTBI showed subtle (i.e., moderate effect sizes) but non-significant deficits on formal neuropsychological testing and during inhibition of return. In contrast, functional imaging results indicated that patients with mTBI demonstrated significantly decreased activation within the bilateral posterior cingulate gyrus, thalamus, basal ganglia, midbrain nuclei, and cerebellum. The spatial topography of hypoactivation was very similar to our previous study in adults, suggesting that subcortical structures may be particularly affected by the initial biomechanical forces in mTBI. Current results also suggest that fMRI may be a more sensitive tool for identifying semi-acute effects of mTBI than the procedures currently used in clinical practice such as neuropsychological testing and structural scans. fMRI findings could potentially serve as a biomarker for measuring the subtle injury caused by mTBI and documenting the course of recovery.
Graduation Date: May 2012
URI: http://hdl.handle.net/1928/20893

Files in this item

Files Size Format View
zhen_dissertation_4_5_2012_final.pdf 1.457Mb PDF View/Open

This item appears in the following Collection(s)

Show full item record

UNM Libraries

Search LoboVault


Advanced Search

Browse

My Account