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Assessment of field effect in the cancerous prostate


Please use this identifier to cite or link to this item: http://hdl.handle.net/1928/20829

Assessment of field effect in the cancerous prostate

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dc.contributor.author Haaland, Christina
dc.date.accessioned 2012-07-05T17:43:14Z
dc.date.available 2012-07-05T17:43:14Z
dc.date.issued 2012-07-05
dc.date.submitted May 2012
dc.identifier.uri http://hdl.handle.net/1928/20829
dc.description.abstract Prostate cancer is the second leading cause of cancer death in men. Prostate Specific Antigen (PSA) is the current indicator of prostate health, and needle core biopsy of the prostate is the standard of cancer diagnosis. However, PSA is not a specific indicator of cancer, and biopsy may miss actual tumor cells, leading to both false positive and false negative results, respectively. Therefore, better indicators of prostate cancer need to be identified. Field effect is the term used to describe the existence of genetically altered, although histologically normal, cells that surround an area of frank cancer. Better understanding and characterization of this field should provide more sensitive means of detecting prostate cancer independent of histological biopsy findings that may miss the tumor. This study furthers field characterization by analyzing various types of genomic and epigenetic alterations, including gene promoter methylation, mRNA expression profiling, changes in telomeres, and genomic instability as reflected by random sites of allelic imbalance. Results demonstrate that this field is predictably altered in cancer. en_US
dc.language.iso en_US en_US
dc.subject prostate cancer en_US
dc.subject field effect en_US
dc.subject telomere en_US
dc.subject allelic imbalance en_US
dc.subject microarray en_US
dc.subject methylation en_US
dc.subject.lcsh Prostate--Cancer--Diagnosis.
dc.subject.lcsh Telomere--Physiology.
dc.subject.lcsh Cancer--Molecular aspects.
dc.title Assessment of field effect in the cancerous prostate en_US
dc.type Dissertation en_US
dc.description.degree Biomedical Sciences en_US
dc.description.level Doctoral en_US
dc.description.department University of New Mexico. Dept. of Biochemistry en_US
dc.description.advisor Griffith, Jeffrey
dc.description.committee-member Bisoffi, Marco
dc.description.committee-member Orlando, Robert
dc.description.committee-member Prosnitz, Eric

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