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dc.contributor.authorHaaland, Christina
dc.date.accessioned2012-07-05T17:43:14Z
dc.date.available2012-07-05T17:43:14Z
dc.date.issued2012-07-05
dc.date.submittedMay 2012
dc.identifier.urihttp://hdl.handle.net/1928/20829
dc.description.abstractProstate cancer is the second leading cause of cancer death in men. Prostate Specific Antigen (PSA) is the current indicator of prostate health, and needle core biopsy of the prostate is the standard of cancer diagnosis. However, PSA is not a specific indicator of cancer, and biopsy may miss actual tumor cells, leading to both false positive and false negative results, respectively. Therefore, better indicators of prostate cancer need to be identified. Field effect is the term used to describe the existence of genetically altered, although histologically normal, cells that surround an area of frank cancer. Better understanding and characterization of this field should provide more sensitive means of detecting prostate cancer independent of histological biopsy findings that may miss the tumor. This study furthers field characterization by analyzing various types of genomic and epigenetic alterations, including gene promoter methylation, mRNA expression profiling, changes in telomeres, and genomic instability as reflected by random sites of allelic imbalance. Results demonstrate that this field is predictably altered in cancer.en_US
dc.language.isoen_USen_US
dc.subjectprostate canceren_US
dc.subjectfield effecten_US
dc.subjecttelomereen_US
dc.subjectallelic imbalanceen_US
dc.subjectmicroarrayen_US
dc.subjectmethylationen_US
dc.subject.lcshProstate--Cancer--Diagnosis.
dc.subject.lcshTelomere--Physiology.
dc.subject.lcshCancer--Molecular aspects.
dc.titleAssessment of field effect in the cancerous prostateen_US
dc.typeDissertationen_US
dc.description.degreeBiomedical Sciencesen_US
dc.description.levelDoctoralen_US
dc.description.departmentUniversity of New Mexico. Dept. of Biochemistryen_US
dc.description.advisorGriffith, Jeffrey
dc.description.committee-memberBisoffi, Marco
dc.description.committee-memberOrlando, Robert
dc.description.committee-memberProsnitz, Eric


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