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dc.contributor.authorCoutsias, Evangelos A.
dc.contributor.authorKo, Junsu
dc.contributor.authorLee, Dongseon
dc.contributor.authorPark, Hahnbeom
dc.contributor.authorLee, Julian
dc.contributor.authorSeok, Chaok
dc.date.accessioned2012-03-20T22:17:35Z
dc.date.available2012-03-20T22:17:35Z
dc.date.issued2011-05-16
dc.identifier.citationNucleic Acids Research, 5/16/2011, 39: 210-214en_US
dc.identifier.issn0305-1048
dc.identifier.urihttp://hdl.handle.net/1928/20176
dc.description.abstractThe FALC-Loop web server provides an online interface for protein loop modeling by employing an ab initio loop modeling method called FALC (fragment assembly and analytical loop closure). The server may be used to construct loop regions in homology modeling, to refine unreliable loop regions in experimental structures or to model segments of designed sequences. The FALC method is computationally less expensive than typical ab initio methods because the conformational search space is effectively reduced by the use of fragments derived from a structure database. The analytical loop closure algorithm allows efficient search for loop conformations that fit into the protein framework starting from the fragment-assembled structures. The FALC method shows prediction accuracy comparable to other state-of-the-art loop modeling methods. Top-ranked model structures can be visualized on the web server, and an ensemble of loop structures can be downloaded for further analysis. The web server can be freely accessed at http://falc-loop.seoklab.org/.en_US
dc.language.isoen_USen_US
dc.publisherOxford University Pressen_US
dc.subjectprotein loopsen_US
dc.titleThe FALC-Loop web server for protein loop modelingen_US
dc.typeArticleen_US


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