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The FALC-Loop web server for protein loop modeling


Please use this identifier to cite or link to this item: http://hdl.handle.net/1928/20176

The FALC-Loop web server for protein loop modeling

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dc.contributor.author Coutsias, Evangelos A.
dc.contributor.author Ko, Junsu
dc.contributor.author Lee, Dongseon
dc.contributor.author Park, Hahnbeom
dc.contributor.author Lee, Julian
dc.contributor.author Seok, Chaok
dc.date.accessioned 2012-03-20T22:17:35Z
dc.date.available 2012-03-20T22:17:35Z
dc.date.issued 2011-05-16
dc.identifier.citation Nucleic Acids Research, 5/16/2011, 39: 210-214 en_US
dc.identifier.issn 0305-1048
dc.identifier.uri http://hdl.handle.net/1928/20176
dc.description.abstract The FALC-Loop web server provides an online interface for protein loop modeling by employing an ab initio loop modeling method called FALC (fragment assembly and analytical loop closure). The server may be used to construct loop regions in homology modeling, to refine unreliable loop regions in experimental structures or to model segments of designed sequences. The FALC method is computationally less expensive than typical ab initio methods because the conformational search space is effectively reduced by the use of fragments derived from a structure database. The analytical loop closure algorithm allows efficient search for loop conformations that fit into the protein framework starting from the fragment-assembled structures. The FALC method shows prediction accuracy comparable to other state-of-the-art loop modeling methods. Top-ranked model structures can be visualized on the web server, and an ensemble of loop structures can be downloaded for further analysis. The web server can be freely accessed at http://falc-loop.seoklab.org/. en_US
dc.language.iso en_US en_US
dc.publisher Oxford University Press en_US
dc.subject protein loops en_US
dc.title The FALC-Loop web server for protein loop modeling en_US
dc.type Article en_US

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