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Matrix metalloproteinases and tissue inhibitors of metalloproteinases in cerebrospinal fluid differ in multiple sclerosis and Devic's neuromyelitis optica

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Please use this identifier to cite or link to this item: http://hdl.handle.net/1928/1924

Matrix metalloproteinases and tissue inhibitors of metalloproteinases in cerebrospinal fluid differ in multiple sclerosis and Devic's neuromyelitis optica

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dc.contributor.author Mandler, RN en_US
dc.contributor.author Dencoff, JD en_US
dc.contributor.author Midani, F en_US
dc.contributor.author Ford, CC en_US
dc.contributor.author Ahmed, W en_US
dc.contributor.author Rosenberg, GA en_US
dc.date.accessioned 2006-09-20T15:10:16Z
dc.date.available 2006-09-20T15:10:16Z
dc.date.issued 2006-09-20T15:10:16Z
dc.identifier.citation 2001 Mar;124(Pt 3):493-8 en_US
dc.identifier.uri http://hdl.handle.net/1928/1924
dc.description For full-test go to PubMed ID: 11222449 en_US
dc.description.abstract Matrix metalloproteinases (MMPs) are increased in the CSF of patients with multiple sclerosis. Devic's neuromyelitis optica (DNO) is a demyelinating syndrome that involves the optic nerve and cervical cord but differs pathologically from multiple sclerosis. Therefore, we hypothesized that the type of inflammatory reaction that causes MMPs to be elevated in multiple sclerosis would be absent in patients with DNO. CSF was collected from 23 patients with relapsing-remitting or secondary progressive multiple sclerosis, all of whom were experiencing acute symptoms, from seven patients with DNO, and from seven normal volunteers. Diagnoses were made according to current criteria on the basis of clinical manifestations, imaging results and CSF studies. IgG synthesis was increased in the CSF of multiple sclerosis patients but not in that of DNO patients. Zymography, reverse zymography and ELISA (enzyme-linked immunosorbent assay) were used to measure gelatinase A (MMP-2), gelatinase B (MMP-9) and tissue inhibitors of metalloproteinases (TIMPs). Zymograms showed that multiple sclerosis patients had elevated MMP-9 compared with DNO patients and controls (P: < 0.05). TIMP-1 and TIMP-2 levels were similar in all three groups. We conclude that multiple sclerosis patients have higher MMP-9 levels in the CSF than patients with DNO, which supports the different pathological mechanisms of these diseases. en_US
dc.format.extent 1767 bytes
dc.format.extent 27648 bytes
dc.format.mimetype text/plain
dc.format.mimetype application/msword
dc.language.iso en_US en_US
dc.publisher Mandler, RN - Brain, a journal of neurology en_US
dc.subject Matrix metalloproteinases en_US
dc.subject tissue inhibitors en_US
dc.subject metalloproteinases en_US
dc.subject cerebrospinal fluid en_US
dc.subject multiple sclerosis en_US
dc.subject Devic's neuromyelitis o en_US
dc.title Matrix metalloproteinases and tissue inhibitors of metalloproteinases in cerebrospinal fluid differ in multiple sclerosis and Devic's neuromyelitis optica en_US


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