LoboVault Home
 

Association of body mass with pulmonary function in the Childhood Asthma Management Program (CAMP

LoboVault

Please use this identifier to cite or link to this item: http://hdl.handle.net/1928/1923

Association of body mass with pulmonary function in the Childhood Asthma Management Program (CAMP

Show full item record

Title: Association of body mass with pulmonary function in the Childhood Asthma Management Program (CAMP
Author: Tantisira, KG; Litonjua, AA; Weiss, ST; Fuhlbrigge, AL; Childhood Asthma Management Program Research Group
Subject(s): body mass
pulmonary function
Childhood Asthma Management Program
CAMP
Abstract: BACKGROUND: While increases in body mass index (BMI) have been associated with the incidence and prevalence of asthma, the mechanisms behind this association are unclear. METHODS: We hypothesised that BMI would be independently associated with measures of asthma severity in a population of children with mild to moderate asthma enrolled in the Childhood Asthma Management Program (CAMP). A multivariable baseline cross sectional analysis of BMI with our outcomes of interest was performed. RESULTS: BMI was generally not associated with symptoms, nor was it associated with atopy. While BMI was positively associated with the methacholine concentration that causes a 20% fall in forced expiratory volume in 1 second (PC(20)FEV(1)), this association did not persist after adjustment for FEV(1). Increasing BMI was associated with increasing FEV(1) (beta = 0.006 l, 95% CI (0.001 to 0.01)) and forced vital capacity (FVC) (beta = 0.012 l, 95% CI (0.007 to 0.017)). However, decrements in the FEV(1)/FVC ratio were noted with increasing BMI (beta = -0.242, 95% CI (-0.118 to -0.366)). Thus, an increase in BMI of 5 units was associated with a decrease in FEV(1)/FVC of over 1%. CONCLUSIONS: Although the association of FEV(1) and FVC with BMI did not support our initial hypothesis, the decrease noted in the FEV(1)/FVC ratio has potential relevance in the relationship between BMI and asthma severity.
Date: 2006-09-20
Publisher: Tantisira, KG - Thorax
Citation: 03 Dec;58(12):1036-41
Description: For full-text go to PubMed ID: 14645968
URI: http://hdl.handle.net/1928/1923

Files in this item

Files Size Format View
Tantisira-14645968.pdf 255.7Kb PDF View/Open

This item appears in the following Collection(s)

Show full item record

UNM Libraries

Search LoboVault


Advanced Search

Browse

My Account