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Isolated thyrotropin deficiency secondary to primary empty sella in a patient with differentiated thyroid carcinoma: an indication for recombinant thyrotropin

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Please use this identifier to cite or link to this item: http://hdl.handle.net/1928/1896

Isolated thyrotropin deficiency secondary to primary empty sella in a patient with differentiated thyroid carcinoma: an indication for recombinant thyrotropin

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dc.contributor.author Colleran, KM en_US
dc.contributor.author Burge, MR en_US
dc.date.accessioned 2006-09-18T21:37:59Z
dc.date.available 2006-09-18T21:37:59Z
dc.date.issued 2006-09-18T21:37:59Z
dc.identifier.citation 1999 Dec;9(12):1249-52 en_US
dc.identifier.uri http://hdl.handle.net/1928/1896
dc.description For full-text go to PubMed, ID: 10646666 en_US
dc.description.abstract The primary empty sella syndrome is a common radiographic finding that is rarely associated with clinical pituitary dysfunction. Studies using dynamic endocrine testing, however, have shown altered pituitary reserve in some patients with the primary empty sella syndrome. We describe a patient with a primary empty sella and an isolated deficiency of thyrotropin reserve. This case is complicated by the presence of an aggressive metastatic papillary epithelial carcinoma of the thyroid. Standard treatment with radioactive iodine was unlikely to be effective in this patient due to the need for adequate thyrotropin (TSH) stimulation of the malignant tissue to optimize uptake of radioactive iodine by the tumor cells. Consequently, this patient was treated with human recombinant TSH before receiving radioactive iodine. The utility of this novel therapeutic agent and a review of hormonal abnormalities associated with the primary empty sella are also discussed. en_US
dc.format.extent 1556 bytes
dc.format.extent 1767 bytes
dc.format.extent 26112 bytes
dc.format.mimetype text/plain
dc.format.mimetype text/plain
dc.format.mimetype application/msword
dc.language.iso en_US en_US
dc.publisher Colleran, KM - Thyroid : official journal of the American Thyroid Association en_US
dc.subject Isolated thyrotropin deficiency en_US
dc.subject differentiated thyroid carcinoma en_US
dc.subject recombinant thyrotropin en_US
dc.subject sella syndrome en_US
dc.title Isolated thyrotropin deficiency secondary to primary empty sella in a patient with differentiated thyroid carcinoma: an indication for recombinant thyrotropin en_US


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