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Methimazole-induced hypothyroidism paradoxically decreases homocysteine.


Please use this identifier to cite or link to this item: http://hdl.handle.net/1928/1731

Methimazole-induced hypothyroidism paradoxically decreases homocysteine.

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dc.contributor.author Colleran, KM en_US
dc.contributor.author Romero, LA en_US
dc.contributor.author Upton, DA en_US
dc.contributor.author Burge, MR en_US
dc.date.accessioned 2006-04-18T19:37:53Z
dc.date.available 2006-04-18T19:37:53Z
dc.date.issued 2005-04
dc.identifier.citation 54(4):460-5 en_US
dc.identifier.uri http://hdl.handle.net/1928/1731
dc.description.abstract Department of Internal Medicine, University of New Mexico, Albuquerque 87131, USA. kcolleran@salud.unm.edu Clinical hypothyroidism is associated with hyperhomocysteinemia, whereas the opposite is seen in hyperthyroidism. The effects of mild thyroid dysfunction on homocysteine concentrations are not known. We performed the following study to investigate this. Total homocysteine, vitamins B6 and B12, folate, fibrinogen, plasminogen activator inhibitor type 1, and lipids were measured in 11 subjects at baseline and after methionine loading. Subjects began methimazole (MMI), 40 mg daily, and were restudied during 2 stages of hypothyroidism. Liothyronine was added and subjects were restudied once thyrotropin normalized. Methimazole was stopped and studies were repeated during 2 stages of hyperthyroidism. Data were analyzed using repeated-measures analysis of variance. Post-methionine homocysteine decreased in each hypothyroid study compared with baseline (28.8+/-10.7, 27.5+/-9.9 vs 34.4+/-9.2 micromol/L, respectively). In addition, both fasting and post-methionine homocysteine decreased in the euthyroid/MMI study arm compared with baseline despite equivalent thyrotropin values (fasting, 7.5+/-3.0 vs 8.8+/-3.5 micromol/L, P<.05; and post-methionine, 27.2+/-10.6 vs 34.4+/-9.2 micromol/L, P<.05, respectively). Fasting homocysteine decreased in the first hyperthyroidism study arm compared with baseline (6.6+/-2.3 vs 8.8+/-3.5 micromol/L, P<.05) and post-methionine homocysteine decreased in both hyperthyroid arms compared with baseline (25.2+/-8.1, 24.2+/-10 vs 34.4+/-9.2 micromol/L, P<.05 respectively). In conclusion, mild thyroid dysfunction changes homocysteine metabolism. Unexpectedly, our results suggest a homocysteine-lowering effect of MMI. en_US
dc.description.sponsorship Study supported by DHHS/NIH/NCRR/GCRC 5M01 RR00997 en_US
dc.format.extent 2691 bytes
dc.format.extent 1832 bytes
dc.format.extent 26624 bytes
dc.format.mimetype text/plain
dc.format.mimetype text/plain
dc.format.mimetype application/msword
dc.language.iso en_US en_US
dc.publisher Metabolism en_US
dc.subject Research Support en_US
dc.subject General Clinical Research Center en_US
dc.title Methimazole-induced hypothyroidism paradoxically decreases homocysteine. en_US
dc.type Article en_US

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