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The relation of BDNF VAL66MET polymorphism to neural volume and drinking behavior among adolescents


Please use this identifier to cite or link to this item: http://hdl.handle.net/1928/13082

The relation of BDNF VAL66MET polymorphism to neural volume and drinking behavior among adolescents

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dc.contributor.author Crotwell, Shirley Mae
dc.date.accessioned 2011-08-30T17:50:26Z
dc.date.available 2011-08-30T17:50:26Z
dc.date.issued 2011-08-30
dc.date.submitted May 2011
dc.identifier.uri http://hdl.handle.net/1928/13082
dc.description.abstract Brain-Derived Neurotrophic Factor (BDNF) plays an important role in neural plasticity, learning and memory. Due to its relation to neurogenesis, BDNF has been studied with respect to its protective effects against various cognitive dysregulations, including those related to alcohol dependence. Recent evidence suggests that alcohol dependent individuals, in addition to those with a family history of alcoholism, have lower basal levels of BDNF as compared to controls. In adult populations, the Met variant of the Val66Met polymorphism, which results in decreased release of BDNF, has been associated with decreased neural volume as well as increased risk for alcohol problems. Using samples with prolonged alcohol exposure makes it difficult to determine the direction of the relationship between neural volume and drinking behavior. Therefore the current study set out to determine whether a relationship between BDNF, neural volume and drinking behavior could be detected using a sample of adolescents. Since this relationship is well demonstrated using adult samples, it was hypothesized that BDNF genotype would be correlated with drinking behavior among adolescents, and this relationship would be mediated by differences in neural volume. 220 adolescents gave saliva samples, participated in magnetic resonance imaging (MRI), and completed behavioral measures designed to assess drinking behavior. Although BDNF was not correlated with drinking behavior, other interesting relationships were discovered including an inverse relationship between age and cerebral cortex volume, a positive relationship between accumbens volume and drinking, and distinct findings based on gender. en_US
dc.language.iso en_US en_US
dc.subject BDNF, Val66Met polymorphism, MRI, adolescents en_US
dc.subject.lcsh Alcoholism--Molecular aspects.
dc.subject.lcsh Alcoholism--Genetic aspects.
dc.subject.lcsh Neurotrophic functions.
dc.title The relation of BDNF VAL66MET polymorphism to neural volume and drinking behavior among adolescents en_US
dc.type Thesis en_US
dc.description.degree Psychology en_US
dc.description.level Masters en_US
dc.description.department University of New Mexico. Dept. of Psychology en_US
dc.description.advisor Hutchison, Kent
dc.description.committee-member Yeo, Ron
dc.description.committee-member Bryan, Angela
dc.description.committee-member Hamilton, Derek

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