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Studies of a cyanine-based biosensor and light-induced antibacterial activities of oligo(phenylene ethynylene)s

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Please use this identifier to cite or link to this item: http://hdl.handle.net/1928/12123

Studies of a cyanine-based biosensor and light-induced antibacterial activities of oligo(phenylene ethynylene)s

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dc.contributor.author Zhou, Zhijun
dc.date.accessioned 2011-02-09T21:36:11Z
dc.date.available 2011-02-09T21:36:11Z
dc.date.issued 2011-02-09
dc.date.submitted December 2010
dc.identifier.uri http://hdl.handle.net/1928/12123
dc.description.abstract This dissertation has been focusing on two subjects: biosensor development and light-activated antimicrobials. A cyanine-based fluorescent biosensor is developed with high sensitivity to detect the presence and activity of caspase-3/7. We demonstrated that supramolecular self-assembly can be useful for designing biosensors. A series of p-Phenylene Ethynylenes (OPEs) have been synthesized. Further photophysical studies show that these molecules have good singlet oxygen yields. The antimicrobial capability increases dramatically when exposed to UV-365 radiation, though dark biocidal activity can be obtained as well. This phenomenon is probably due to the high yields of singlet oxygen of these OPEs, which oxidizes unsaturated membrane and inner components of bacteria, such as protein, DNA, etc. viii Coupled with our previous work about the interactions of EO-OPE-1s with DOPC/cholesterol vesicles, we believe the biocidal process involves (1) EO-OPE-1s penetrate the bacterial membrane, (2) EO-OPE-1s photosensitize the generation of singlet oxygen and other reactive oxygen species and (3) singlet oxygen and/or reactive oxygen species trigger the cytotoxicity. en_US
dc.language.iso en_US en_US
dc.subject biocides en_US
dc.subject self-assembly en_US
dc.subject singlet oxygen en_US
dc.subject Light-induced en_US
dc.subject Biosensor en_US
dc.subject cyanine en_US
dc.subject ope en_US
dc.title Studies of a cyanine-based biosensor and light-induced antibacterial activities of oligo(phenylene ethynylene)s en_US
dc.type Dissertation en_US
dc.description.degree Chemistry en_US
dc.description.level Doctoral en_US
dc.description.department University of New Mexico. Dept. of Chemistry en_US
dc.description.advisor Whitten, David
dc.description.committee-member Keller, David
dc.description.committee-member Canavan, Heather
dc.description.committee-member Guo, Hua
dc.description.committee-member Schanze, Kirk
dc.description.committee-member Whitten, David


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