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dc.contributor.authorZhou, Zhijun
dc.date.accessioned2011-02-09T21:36:11Z
dc.date.available2011-02-09T21:36:11Z
dc.date.issued2011-02-09
dc.date.submittedDecember 2010
dc.identifier.urihttp://hdl.handle.net/1928/12123
dc.description.abstractThis dissertation has been focusing on two subjects: biosensor development and light-activated antimicrobials. A cyanine-based fluorescent biosensor is developed with high sensitivity to detect the presence and activity of caspase-3/7. We demonstrated that supramolecular self-assembly can be useful for designing biosensors. A series of p-Phenylene Ethynylenes (OPEs) have been synthesized. Further photophysical studies show that these molecules have good singlet oxygen yields. The antimicrobial capability increases dramatically when exposed to UV-365 radiation, though dark biocidal activity can be obtained as well. This phenomenon is probably due to the high yields of singlet oxygen of these OPEs, which oxidizes unsaturated membrane and inner components of bacteria, such as protein, DNA, etc. viii Coupled with our previous work about the interactions of EO-OPE-1s with DOPC/cholesterol vesicles, we believe the biocidal process involves (1) EO-OPE-1s penetrate the bacterial membrane, (2) EO-OPE-1s photosensitize the generation of singlet oxygen and other reactive oxygen species and (3) singlet oxygen and/or reactive oxygen species trigger the cytotoxicity.en_US
dc.language.isoen_USen_US
dc.subjectbiocidesen_US
dc.subjectself-assemblyen_US
dc.subjectsinglet oxygenen_US
dc.subjectLight-induceden_US
dc.subjectBiosensoren_US
dc.subjectcyanineen_US
dc.subjectopeen_US
dc.titleStudies of a cyanine-based biosensor and light-induced antibacterial activities of oligo(phenylene ethynylene)sen_US
dc.typeDissertationen_US
dc.description.degreeChemistryen_US
dc.description.levelDoctoralen_US
dc.description.departmentUniversity of New Mexico. Dept. of Chemistryen_US
dc.description.advisorWhitten, David
dc.description.committee-memberKeller, David
dc.description.committee-memberCanavan, Heather
dc.description.committee-memberGuo, Hua
dc.description.committee-memberSchanze, Kirk
dc.description.committee-memberWhitten, David


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