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Decreased functional connectivity with aging and disease duration in schizophrenia

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Please use this identifier to cite or link to this item: http://hdl.handle.net/1928/10343

Decreased functional connectivity with aging and disease duration in schizophrenia

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dc.contributor.author Abbott, Christopher
dc.date.accessioned 2010-02-09T21:56:50Z
dc.date.available 2010-02-09T21:56:50Z
dc.date.issued 2010-02-09T21:56:50Z
dc.date.submitted December 2009
dc.identifier.uri http://hdl.handle.net/1928/10343
dc.description.abstract Objective: Progressive brain changes late in the disease course of schizophrenia may be detected with functional connectivity. This study compared functional connectivity between patients with schizophrenia late in the disease course with matched healthy controls. Method: Subjects included 18 patients with schizophrenia with minimum 15 years disease duration and 28 matched healthy controls from the MIND Clinical Imaging Consortium database. The functional magnetic resonance imaging paradigm was the auditory oddball task. We used independent components analysis to identify temporally cohesive but spatially distributed neural networks. We selected the executive control and default mode networks for additional analysis. The temporal course of each spatial component was then regressed with a model of the hemodynamic time course based on the experimental paradigm to measure functional connectivity. The beta weights from this regression were used for additional group level analysis. Results: The anterior default mode network had a main effect by group (patients with schizophrenia and healthy controls) and an interaction with group and aging. As the patient group aged, they had less negative modulation of the anterior default mode network. The patient group also had significantly less positive modulation of the executive control network. Conclusions: These results show evidence of changes in functional connectivity in the anterior default mode network late in the disease course of schizophrenia. The decreased functional connectivity may be attributable to the progressive disease course of schizophrenia. en_US
dc.language.iso en_US en_US
dc.subject Schizophrenia en_US
dc.subject fMRI en_US
dc.subject Indepent Component Analysis en_US
dc.subject Duration of Illness en_US
dc.subject.lcsh Schizophrenia--Longitudinal studies.
dc.subject.lcsh Brain--Magnetic resonsnce imaging.
dc.title Decreased functional connectivity with aging and disease duration in schizophrenia en_US
dc.type Thesis en_US
dc.description.degree Masters of Science in Biomedical Sciences Clinical Research en_US
dc.description.level Masters en_US
dc.description.department University of New Mexico. Biomedical Sciences Graduate Program en_US
dc.description.advisor Bustillo, Juan
dc.description.committee-member Calhoun, Vince
dc.description.committee-member Shuttleworth, Bill


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