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dc.contributor.authorXu, Grace
dc.date.accessioned2009-09-02T20:58:16Z
dc.date.available2009-09-02T20:58:16Z
dc.date.issued2009-09-02T20:58:16Z
dc.identifier.urihttp://hdl.handle.net/1928/9866
dc.description.abstractReducing the volume of brain damage after stroke has been a focus of recent research due to its effect on recovery time and quality of life. Changes in proteasomal activities are related to ischemic damage of brain. Proteasome inhibition has been suggested as a potential treatment option for stroke. However, the mechanism of alteration of proteasomal activities in neurons under ischemic conditions is not known. In study, we investigated the role of glucose in regulating proteasomal activities in neuronal cells under ischemic condition. We found that glucose concentration had remarkable differential effect on both 20S and 26S proteasomal activities in SH-SY5Y cells under hypoxic exposures. Further investigation revealed that reactive oxygen species caused increase or decrease of 20S and 26S activities, dependent on the level of ROS. Finally,antioxidant treatment confirmed that ROS was responsible, at least in part, for the changes of proteasomal activities in ischemic neurons.en_US
dc.language.isoenen_US
dc.subjectGlucoseen_US
dc.subjectProteasome activitiesen_US
dc.subjectin vitro ischemiaen_US
dc.subjectneuronal cellsen_US
dc.titleThe effects of glucose on proteasome activities in neuronal cells under in vitro ischemia conditionsen_US
dc.typePresentationen_US


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