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The effects of glucose on proteasome activities in neuronal cells under in vitro ischemia conditions

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Please use this identifier to cite or link to this item: http://hdl.handle.net/1928/9866

The effects of glucose on proteasome activities in neuronal cells under in vitro ischemia conditions

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dc.contributor.author Xu, Grace
dc.date.accessioned 2009-09-02T20:58:16Z
dc.date.available 2009-09-02T20:58:16Z
dc.date.issued 2009-09-02T20:58:16Z
dc.identifier.uri http://hdl.handle.net/1928/9866
dc.description.abstract Reducing the volume of brain damage after stroke has been a focus of recent research due to its effect on recovery time and quality of life. Changes in proteasomal activities are related to ischemic damage of brain. Proteasome inhibition has been suggested as a potential treatment option for stroke. However, the mechanism of alteration of proteasomal activities in neurons under ischemic conditions is not known. In study, we investigated the role of glucose in regulating proteasomal activities in neuronal cells under ischemic condition. We found that glucose concentration had remarkable differential effect on both 20S and 26S proteasomal activities in SH-SY5Y cells under hypoxic exposures. Further investigation revealed that reactive oxygen species caused increase or decrease of 20S and 26S activities, dependent on the level of ROS. Finally,antioxidant treatment confirmed that ROS was responsible, at least in part, for the changes of proteasomal activities in ischemic neurons. en_US
dc.language.iso en en_US
dc.subject Glucose en_US
dc.subject Proteasome activities en_US
dc.subject in vitro ischemia en_US
dc.subject neuronal cells en_US
dc.title The effects of glucose on proteasome activities in neuronal cells under in vitro ischemia conditions en_US
dc.type Presentation en_US


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