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Increased expression of MAD2 occurs in association with DNMT1 protein stabilization and aberrant CpG island promoter hypermethylation during carcinogenesis in immortalized bronchial epithelial cells

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Please use this identifier to cite or link to this item: http://hdl.handle.net/1928/9858

Increased expression of MAD2 occurs in association with DNMT1 protein stabilization and aberrant CpG island promoter hypermethylation during carcinogenesis in immortalized bronchial epithelial cells

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Title: Increased expression of MAD2 occurs in association with DNMT1 protein stabilization and aberrant CpG island promoter hypermethylation during carcinogenesis in immortalized bronchial epithelial cells
Author: Romo, Paul
Subject(s): MAD2
DNMT1 protein stabilization
CpG
hypermethylation
carcinogenesis
bronchial epithelial cells
Abstract: Physicians and scientists must join together and research the specific effects of environmental carcinogens in relation to cancer. A great model to study environmental carcinogenesis is carcinogen-induced lung cancer. We know that 30% of cancer deaths are accredited to lung cancer and that cigarette smoking is the number one cause of lung cancer, other forms of cancer, and cancer deaths worldwide (1). Second hand smoke is also a very serious health concern. Second hand smoke has been chosen as a cancer-causing agent by the U.S. Environmental Protection Agency, the National Toxicology Program and the International Agency for Research on Cancer (IARC) because this extremely deadly agent is known to contain hundreds of chemicals known to be toxic or carcinogenic.
Date: 2009-09-01
URI: http://hdl.handle.net/1928/9858

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