LoboVault Home
 

Using the Noninformative Families in Family-Based Association Tests: A Powerful New Testing Strategy

LoboVault

Please use this identifier to cite or link to this item: http://hdl.handle.net/1928/2378

Using the Noninformative Families in Family-Based Association Tests: A Powerful New Testing Strategy

Show full item record

Title: Using the Noninformative Families in Family-Based Association Tests: A Powerful New Testing Strategy
Author: Lange, C; Demeo, D; Silverman, EK; Weiss, ST; Laird, NM
Subject(s): Family Testing
Lungs - Disease
Obstructive
Phenotype
Methodology
Abstract: For genetic association studies with multiple phenotypes, we propose a new strategy for multiple testing with family-based association tests (FBATs). The strategy increases the power by both using all available family data and reducing the number of hypotheses tested while being robust against population admixture and stratification. By use of conditional power calculations, the approach screens all possible null hypotheses without biasing the nominal significance level, and it identifies the subset of phenotypes that has optimal power when tested for association by either univariate or multivariate FBATs. An application of our strategy to an asthma study shows the practical relevance of the proposed methodology. In simulation studies, we compare our testing strategy with standard methodology for family studies. Furthermore, the proposed principle of using all data without biasing the nominal significance in an analysis prior to the computation of the test statistic has broad and powerful applications in many areas of family-based association studies.
Date: 2003-10
Publisher: University of Chicago Press; Lange, C
Citation: American Journal of Human Genetics, Oct2003, Vol. 73 Issue 4, p801, 11p
Series: 73
4
Description: PubMed ID: 14502464
URI: http://hdl.handle.net/1928/2378
ISSN: 0002-9297

Files in this item

Files Size Format View
Lange-14502464.pdf 154.2Kb PDF View/Open

This item appears in the following Collection(s)

Show full item record

UNM Libraries

Search LoboVault


Advanced Search

Browse

My Account