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Power and Design Considerations for a General Class of Family-Based Association Tests: Quantitative Traits

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Please use this identifier to cite or link to this item: http://hdl.handle.net/1928/2377

Power and Design Considerations for a General Class of Family-Based Association Tests: Quantitative Traits

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dc.contributor.author Lange, C
dc.contributor.author DeMeo, DL
dc.contributor.author Laird, NM
dc.date.accessioned 2006-10-30T16:53:59Z
dc.date.available 2006-10-30T16:53:59Z
dc.date.issued 2002-12
dc.identifier.citation American Journal of Human Genetics, Dec2002, Vol. 71 Issue 6, p1330, 12p en_US
dc.identifier.issn 0002-9297
dc.identifier.uri http://hdl.handle.net/1928/2377
dc.description PubMed ID: 12454799 en
dc.description.abstract In the present article, we address family-based association tests (FBATs) for quantitative traits. We propose an approach to analytical power and sample-size calculations for general FBATs; this approach can be applied to virtually any scenario (missing parental information, multiple offspring per family, etc.). The power calculations are used to discuss optimal choices of the phenotypes for the FBAT statistic and its power's dependence on ascertainment conditions, on study design, and on the correct specification of the distributional assumptions for the phenotypes. We also compare the general FBAT approach with PDT and QTDT. The practical relevance of our theoretical considerations is illustrated by their application to an asthma study. en_US
dc.format.extent 167322 bytes
dc.format.mimetype application/pdf
dc.language.iso en_US en_US
dc.publisher University of Chicago Press; Lange, C. en_US
dc.relation.ispartofseries 71 en
dc.relation.ispartofseries 6 en
dc.subject Association tests en_US
dc.subject Genetics en_US
dc.title Power and Design Considerations for a General Class of Family-Based Association Tests: Quantitative Traits en_US
dc.type Article en_US


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