LoboVault Home
 

Ethanol exposure impairs glutamatergic synaptic transmission and plasticity in the ca1 hippocampal region during the third trimester-equivalent of human pregnancy : implications for fetal alcohol spectrum disorder

LoboVault

Please use this identifier to cite or link to this item: http://hdl.handle.net/1928/20866

Ethanol exposure impairs glutamatergic synaptic transmission and plasticity in the ca1 hippocampal region during the third trimester-equivalent of human pregnancy : implications for fetal alcohol spectrum disorder

Show simple item record

dc.contributor.author Puglia, Michael
dc.date.accessioned 2012-07-05T22:10:50Z
dc.date.available 2012-07-05T22:10:50Z
dc.date.issued 2012-07-05
dc.date.submitted May 2012
dc.identifier.uri http://hdl.handle.net/1928/20866
dc.description.abstract Fetal alcohol spectrum disorder results from developmental exposure to ethanol. Although many organ systems are targeted by this teratogen, the central nervous system is exquisitely sensitive. Children with this disease often present with behavioral disorders as well as impairments in learning and memory. Ethanol exposure affects developmental processes throughout pregnancy; however, the third trimester-equivalent has demonstrated heightened sensitivity. Although the mechanism of action(s) of ethanol remains unknown, studies suggest that impairments in glutamatergic signaling and synaptic plasticity during the third trimester-equivalent period of development lead to alterations in synaptic formation and refinement. However, little is known about the developmental effects of ethanol in the CA1 hippocampal region, a brain region often studied in the context of learning and memory. Studies presented in this dissertation address the acute and chronic effects of ethanol during the third trimester-equivalent period. First, characterization of the acute effects of ethanol demonstrated postsynaptic inhibition of both NMDA receptor (NMDAR) and AMPA receptor (AMPAR) mediated synaptic responses, as well as the inhibition of long-term potentiation (LTP) induction. Then, an in vivo repeated ethanol exposure paradigm was used to mimic maternal drinking during this period. In contrast to the effects of acute ethanol exposure, repeated exposure did not affect AMPAR- or NMDAR-mediated synaptic strength or glutamate release; however, it impaired LTP expression and/or maintenance. Lastly, repeated in vivo third trimester-equivalent ethanol exposure did not affect expression of Ca2+-permeable AMPARs, or induce tolerance to the acute inhibitory effects of ethanol. Studies in this dissertation add to a growing body of evidence indicating that significant differences exist between the effects of ethanol on the developing versus the mature brain. Furthermore, studies presented here support the notion that ethanol-mediated impairments in synaptic plasticity mechanisms during the third trimester-equivalent developmental period could lead to inappropriate wiring of neuronal circuitry, and set the stage for the long term deficits observed in children with fetal alcohol spectrum disorder. en_US
dc.description.sponsorship National Institute on Alcohol Abuse and Alcoholism, University of New Mexico MD/PhD Program en_US
dc.subject ethanol en_US
dc.subject development en_US
dc.subject plasticity en_US
dc.subject glutamate en_US
dc.subject syanptic en_US
dc.subject.lcsh Fetal alcohol syndrome.
dc.subject.lcsh Alcohol--Pathophysiology.
dc.subject.lcsh Neurotoxicology.
dc.subject.lcsh Neural transmission.
dc.subject.lcsh Neuroplasticity.
dc.subject.lcsh Glutamic acid.
dc.subject.lcsh Hippocampus (Brain)
dc.title Ethanol exposure impairs glutamatergic synaptic transmission and plasticity in the ca1 hippocampal region during the third trimester-equivalent of human pregnancy : implications for fetal alcohol spectrum disorder en_US
dc.type Dissertation en_US
dc.description.degree Biomedical Sciences en_US
dc.description.level Doctoral en_US
dc.description.department University of New Mexico. Biomedical Sciences Graduate Program en_US
dc.description.advisor Valenzuela, Carlos Fernando
dc.description.committee-member Partridge, Don
dc.description.committee-member Shuttleworth, Bill
dc.description.committee-member Mueller, Wolfgang


Files in this item

Files Size Format View Description
M_Puglia_Dissertation_Final.pdf 1.879Mb PDF View/Open Dissertation pdf

This item appears in the following Collection(s)

Show simple item record

UNM Libraries

Search LoboVault


Advanced Search

Browse

My Account