LoboVault Home
 

Immune regulation and Fc(alpha)RI Recognition and activation by C-reactive protein

LoboVault

Please use this identifier to cite or link to this item: http://hdl.handle.net/1928/20843

Immune regulation and Fc(alpha)RI Recognition and activation by C-reactive protein

Show full item record

Title: Immune regulation and Fc(alpha)RI Recognition and activation by C-reactive protein
Author: Marjon, Kristopher
Advisor(s): Du Clos, Terry
Committee Member(s): Mold, Carolyn
Prossnitz, Eric
Gresham, Hattie
Department: University of New Mexico. Biomedical Sciences Graduate Program
Subject(s): C-REACTIVE PROTEIN
MACROPHAGE
CD89
Fc alpha RI
CD64
LC Subject(s): C-reactive protein.
Fc receptors.
Immunoglobulins.
Inflammation--Mediators
Degree Level: Doctoral
Abstract: The acute phase serum protein C-reactive protein (CRP) is one of the major responding proteins during inflammation response in humans. CRP is a serum pattern recognition molecule that can bind to dead or damaged cells and bacteria to initiate their clearance through interaction with immunoglobulin receptors expressed on the surface of immune cells. Immunoglobulin receptors are traditionally thought to bind exclusively to the fragment crystallizable (Fc) region of immunoglobulins and are consequently called Fc receptors (FcRs). FcRs have been shown to play an immunoregulatory role by either exacerbating inflammatory states or potently inhibiting or reversing inflammation. CRP has been proposed to act through FcRs either promoting inflammation or resolving an inflammatory insult. Immunosuppressive properties have been demonstrated for CRP in mouse models of immune complex mediated inflammation and autoimmune disease. However, the initiating and downstream mechanisms of this process have not been investigated. This dissertation uses an adoptive cell transfer model in mice to address the immunosuppressive capacity of CRP. In this model, treatment of donor spleen cells with CRP suppresses the induced platelet clearance in recipient mice and indicates that protection by CRP is dependent on expression of FcγRI on donor macrophages and FcγRIIb in the recipient mouse. As an extension of the work characterizing CRP-FcR interactions, this dissertation also describes the IgA Fc receptor I (FcαRI) as a novel receptor for CRP. The interaction between CRP and FcαRI induces cytokine production, enhances phagocytosis and alters surface expression of FcαRI on human neutrophils. Collectively, these findings highlight key components in CRP-mediated immunosuppression and a novel receptor for CRP, indicating the complex role this ancient molecule has in the human immune system.
Graduation Date: May 2012
URI: http://hdl.handle.net/1928/20843

Files in this item

Files Size Format View Description
Kristopher Marjon Dissertation FINAL.pdf 136.5Mb PDF View/Open Marjon Dissertation

This item appears in the following Collection(s)

Show full item record

UNM Libraries

Search LoboVault


Advanced Search

Browse

My Account