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Assessment of field effect in the cancerous prostate

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Please use this identifier to cite or link to this item: http://hdl.handle.net/1928/20829

Assessment of field effect in the cancerous prostate

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Title: Assessment of field effect in the cancerous prostate
Author: Haaland, Christina
Advisor(s): Griffith, Jeffrey
Committee Member(s): Bisoffi, Marco
Orlando, Robert
Prosnitz, Eric
Department: University of New Mexico. Dept. of Biochemistry
Subject: prostate cancer
field effect
telomere
allelic imbalance
microarray
methylation
LC Subject(s): Prostate--Cancer--Diagnosis.
Telomere--Physiology.
Cancer--Molecular aspects.
Degree Level: Doctoral
Abstract: Prostate cancer is the second leading cause of cancer death in men. Prostate Specific Antigen (PSA) is the current indicator of prostate health, and needle core biopsy of the prostate is the standard of cancer diagnosis. However, PSA is not a specific indicator of cancer, and biopsy may miss actual tumor cells, leading to both false positive and false negative results, respectively. Therefore, better indicators of prostate cancer need to be identified. Field effect is the term used to describe the existence of genetically altered, although histologically normal, cells that surround an area of frank cancer. Better understanding and characterization of this field should provide more sensitive means of detecting prostate cancer independent of histological biopsy findings that may miss the tumor. This study furthers field characterization by analyzing various types of genomic and epigenetic alterations, including gene promoter methylation, mRNA expression profiling, changes in telomeres, and genomic instability as reflected by random sites of allelic imbalance. Results demonstrate that this field is predictably altered in cancer.
Graduation Date: May 2012
URI: http://hdl.handle.net/1928/20829


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