LoboVault Home
 

Association of hypothalamic-pituitary-adrenal axis function with neuropsychological performance in children with mild/moderate asthma

LoboVault

Please use this identifier to cite or link to this item: http://hdl.handle.net/1928/1917

Association of hypothalamic-pituitary-adrenal axis function with neuropsychological performance in children with mild/moderate asthma

Show full item record

Title: Association of hypothalamic-pituitary-adrenal axis function with neuropsychological performance in children with mild/moderate asthma
Author: Annett, RD; Stansbury, K; Kelly, HW; Strunk, RC
Subject(s): hypothalamic-pituitary-adrenal
neuropsychological performance
mild/moderate asthma
Abstract: The present study examines the relationship between hypothalamic-pituitary-adrenal (HPA) axis function and child psychological/neuropsychological function in a group of children with mild to moderate asthma. The goal of the study was to determine whether child neuropsychological functioning and psychological functioning were associated with cortisol production in response to adrenocorticotropic hormone(ACTH) stimulation when assessed as area under the curve. Data for this study were gathered from 63 children who participated in an ancillary study within the Childhood Asthma Management Program (CAMP) during the pre-randomization phase of the CAMP trial. At 2 of the 8 CAMP clinical centers participants completed an ACTH stimulation test after an overnight stay in the General Clinical Research Center. Gender differences on baseline cortisol and change in cortisol 30 minutes after infusion of ACTH were present. Results further indicated significant associations between cortisol production and measures of child neuropsychological function. Stepwise multiple regression analysis revealed that cortisol change could be predicted by measures of gender, working memory, and arousal maintenance, providing support for the hypothesis that cortisol plays a modest role in the neuropsychological function of children with mild and moderate asthma. In contrast, cortisol production was not associated with child reports of psychological functioning. Limitations to the methods employed in this study are discussed.
Date: 2006-09-20
Publisher: Annett, RD - Child neuropsychology : a journal on normal and abnormal development in childhood and adolescence
Citation: 2005 Aug;11(4):333-48
Description: For full-text go to PubMed ID: 16051562
URI: http://hdl.handle.net/1928/1917

Files in this item

Files Size Format View
Annett-16051562.doc 26Kb Microsoft Word View/Open

This item appears in the following Collection(s)

Show full item record

UNM Libraries

Search LoboVault


Advanced Search

Browse

My Account