Biomedical Engineering ETDs

Andrew Gomez

Publication Date

9-1-2015

Abstract

This work investigates polymeric coating of evaporated induced self-assembly (EISA) mesoprous silica nanoparticles for potential use in controlled drug release and therapeutics. As demonstrated here, lipid bilayer coatings can be easily replaced with different polymer analogs allowing for dynamic response to environmental stimuli. In addition to coupling commercially available diblock polymers we synthesized and characterized a unique dual hydrophilic pH responsive diblock copolymer, PEO-PAA. This hybrid polymeric-nanoparticle system drastically improves targeting and release capabilities through the modular ability to couple multiple different polymers. Furthermore, this work is supported by an improved method to form and study giant polymer vesicles (pGVs)

Language

English

Keywords

giant polymer vesicles, pGVs, pH responsive polymers, protocell, dual-hydrophilic, PEO-PAA, MSNs

Document Type

Thesis

Degree Name

Biomedical Engineering

Level of Degree

Masters

Department Name

Biomedical Engineering

First Committee Member (Chair)

C. Jeffrey Brinker

Second Committee Member

Eric C. Carnes

Third Committee Member

Carlee E. Ashley

Project Sponsors

This work was sponsored by the Center for Integrated Nanotechnologies: user proposal C2014B0059, the Advanced Materials Laboratory, and in part by BES-MSE

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